Pharmaceutical compound and process of making same



--lhe 'achoi'r'oi icuti'iydisuliouic acid on alou- -intense and disagreeable taste and smell of.

Unrrua dramas Parent AltlllUlt EICIIENGRUN, OF ELBE'RFELD, GERMANY, ASSIGNOR TO THE FAR BENFABRIKEN 0F ELBERFEED COMPANY, OF NEW YORK.

ru/mwmcru'ntticourouuo AND rsocEss or ammo SAME.

SPECII IGihilION forming part of Letters Patent No. 626,413, dated June 6, 1899.

Application filed February 17, 1899.-

ToaZZ whom it may concern.-

Be it known that I, ARTHUREIUIIENGRUN, doctor of philosophy, chemist, of Elberfeld, Germany, (assignor to the FARBENFABRIKEN 0F ELBERFELD COMPANY, of New York, have invented a new and useful Improvement in Pharmaceutical Compon ads; and I hereby declare the following to be a clear and exact description of my invention.

The reaction product which is obtained by men compounds cannot be used as a remedy for mtestinal diseases, because it exhibits the ichthyol. I have now found that by heating the said product with formic aldehyde it is transformed into anew methylene derivative, which is a, tasteless and odorl nn tinfcuni; and which is, therefore, well adapted for use as an'internai remedy.

In carrying out my new process practically I may proceed as follows: Twelve hundred and fifty grams of ichthyolsulfonic acid are stirred into a solution prepared from one kilo, by weight, of an albumen compound-say egg albumen-and' ten liters of water The re sulting mixture is heated on a water-hath until a coagulated precipitate has separated at the bottom of the vessel. The liquid is'then' poured oif and replaced by fresh Water. Suhsequently one hundred cubic centimeters of a tcu-per-centsformic-aldehyde solution are added,a.n' the resulting mixture is heated on the waterfiltered off, dried, and pulverized. Thus a grayish-yellow amorphous powdjar is obtained what I claimita.

athto boiling. The precipitate is then Serial No. 705,791. {No specimens.)

It is insoluble in water, alcohol, other, and

benzene. By dilute acids it is-not deconr posed; but it is slowly dissolved by the action of dilute allcalies. Owing to these properties the new product can be employed with advantage as an internal remedy.

Having now described my invention and in what manner the'smne is to be performed,

1. Thelprocess for producing a new phao maceutical compound, which process consists in first heating the precipitate obtained by the action of ichthyolsulfonic acid on albu inens with a formic-aldehyde solution, cubse quently filtering and dr iug the new compound ihus obtained, su stantially as hereinbefore described.

2. As a new article of manufacture the new pharmaceutical compound obtainable from foruiz'c aldehyde, albumens and ichthyolsnh fonic acid, which is a grayish-yellow, practically tasteless and odorless powder insoluble in water, alcohol, ether, benzene and in dilute acids, and which is slowly dissolved by the action of dilute alkalies, substantially as hereinbefore described. I

In testimony whereof I have signed my name in the presence of two subsprihing witnesses.

ARTHUR EICIIENGR'UN.

\Vitnesees:

R. E. J Ann, O'r'ro Komo.

neWbend-desirem secure by iletters latent, 1s-

Qorreciion i5 It-is hereby certified that in Letters Patent No. 626,413, granted J mm 6, 1899, upon the application of Arthur Eiohengr'i'm, of E1berfe1d,"Gormany, for an improvcmen in Phamuceutical Compounds and Processes of Making Same, an error ap ears in the printed specification requiring correction as follows: In line 32, the words tenper-cent. should read forty-per-cent; and that the said Letters Patent should be read with this correction therein th t the same may conform to the record of the case in the Patent Office.

Signed, oountersigned, and sealed this 20th day of June, A. 1)., 1899.

[SEAL] WEBS'EER DAVIS,

Assistant Secretary of the Interior. Couz'xtol'signed DUELL, Omrmtisaionev of Patents. 

